7Y1H: Controlling fibrosis using compound with novel binding mode to prolyl-tRNA synthetase 1

PDB ID: 7Y1HDownload
MMDB ID: 232267
PDB Deposition Date: 2022/6/8
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 1.99  Å
Source Organism:
Similar Structures:
Biological Unit for 7Y1H: dimeric; determined by author and by software (PISA)
Molecular Components in 7Y1H
Label Count Molecule
Proteins (2 molecules)
2
Bifunctional Glutamate/proline--trna Ligase
(Gene symbol: EPRS1)
Molecule annotation
Chemicals and Non-standard biopolymers (10 molecules)
1
2
1-(5-chloranyl-4-methyl-benzimidazol-1-yl)-3-[(2R,3S)-3-oxidanylpiperidin-2-yl]propan-2-one1-(5-chloranyl-4-methyl-benzimidazol-1-yl)-3-[(2R,3S)-3-oxidanylpiperidin-2-yl]propan-2-one
2
2
ADENOSINE-5'-TRIPHOSPHATEADENOSINE-5'-TRIPHOSPHATE
3
2
ZINC IONZINC ION
4
4
MAGNESIUM IONMAGNESIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303