National Center for
Biotechnology Information

7X8X: structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications for developing antimicrobial agents targeting Clp protease

PDB ID:

MMDB ID:

228875

PDB Deposition Date:

2022/3/15

Updated in MMDB:

2023/12

Experimental Method:

x-ray diffraction

Resolution:

3.24 Å

Source Organism:

Mycobacterium tuberculosis CDC1551▼

Taxonomy	Molecule
Mycobacterium tuberculosis CDC1551	A, O, C, Q, F, S, H, T, J, V, L, X, E, a
synthetic construct	c, e, f, g, h, i, j, k, l, m, n, o, p, q, r, s, t, u, v, w, x, y, z, 0, 1, 2, 3, 4
Mycobacterium tuberculosis	B, P, D, R, I, U, K, W, M, Y, N, Z, G, b

Similar Structures:

Biological Unit for 7X8X: 56-meric; determined by author

Molecular Components in 7X8X
Label	Count	Molecule
Proteins (56 molecules)
A O C Q F S H T J V L X E a	14	Atp-dependent CLP Protease Proteolytic Subunit 2
B P D R I U K W M Y N Z G b	14	Atp-dependent CLP Protease Proteolytic Subunit 1
c e f g h i j k l m n o p q r s t u v w x y z 0 1 2 3 4	28	4-[[3,5-bis(fluoranyl)phenyl]methyl]-n-[(4-bromophenyl)methyl]piperazine-1-carboxamide
Chemicals and Non-standard biopolymers (14 molecules)
1	14	4-[1-[3-[4-[(4-fluoranyl-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-quinazolin-7-yl]oxypropyl]piperidin-4-yl]benzamide

* Click molecule labels to explore molecular sequence information.

Citing MMDB