7X09: Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with inhibitors L95 and Halofuginone

PDB ID: 7X09Download
MMDB ID: 234636
PDB Deposition Date: 2022/2/21
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 1.7  Å
Source Organism:
Similar Structures:
Biological Unit for 7X09: dimeric; determined by author and by software (PISA)
Molecular Components in 7X09
Label Count Molecule
Proteins (2 molecules)
2
Bifunctional Glutamate/proline--trna Ligase
(Gene symbol: EPRS1)
Molecule annotation
Chemicals and Non-standard biopolymers (16 molecules)
1
2
7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one
2
2
~{N}-[4-[(3~{S})-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-6-methyl-pyridin-2-yl]-2-phenyl-ethanamide~{N}-[4-[(3~{S})-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-6-methyl-pyridin-2-yl]-2-phenyl-ethanamide
3
4
ZINC IONZINC ION
4
2
BROMIDE IONBROMIDE ION
5
3
CALCIUM IONCALCIUM ION
6
1
GLYCEROLGLYCEROL
7
2
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303