7UMB: NanoBRET tracer Tram-bo bound to a KSR2-MEK1 complex

PDB ID: 7UMBDownload
MMDB ID: 236044
PDB Deposition Date: 2022/4/6
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 3.231  Å
Source Organism:
Similar Structures:
Biological Unit for 7UMB: dimeric; determined by author and by software (PISA)
Molecular Components in 7UMB
Label Count Molecule
Proteins (2 molecules)
1
Kinase Suppressor of RAS 2
(Gene symbol: KSR2)
Molecule annotation
1
Dual Specificity Mitogen-activated Protein Kinase Kinase 1
(Gene symbol: MAP2K1)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
2
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTERPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
2
1
{3-[(1M,2M)-2-{[(1S,2P)-1H,1'H-[2,2'-bipyrrol]-5-yl-kappaN~1~]methylidene}-2H-pyrrol-5-yl-kappaN]-N-(2-{2-[3-({(3M)-3-[(4aM)-3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl}amino)-3-oxopropoxy]ethoxy}ethyl)propanamidato}(difluorido)boron{3-[(1M,2M)-2-{[(1S,2P)-1H,1'H-[2,2'-bipyrrol]-5-yl-kappaN~1~]methylidene}-2H-pyrrol-5-yl-kappaN]-N-(2-{2-[3-({(3M)-3-[(4aM)-3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl}amino)-3-oxopropoxy]ethoxy}ethyl)propanamidato}(difluorido)boron
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303