7T1D: Human SIRT2 in complex with small molecule 359

PDB ID: 7T1DDownload
MMDB ID: 230151
PDB Deposition Date: 2021/12/1
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.75  Å
Source Organism:
Similar Structures:
Biological Unit for 7T1D: dimeric; determined by author and by software (PISA)
Molecular Components in 7T1D
Label Count Molecule
Proteins (2 molecules)
2
Nad-dependent Protein Deacetylase Sirtuin-2
(Gene symbol: SIRT2)
Molecule annotation
Chemicals and Non-standard biopolymers (17 molecules)
1
2
ZINC IONZINC ION
2
4
SULFATE IONSULFATE ION
3
7
1,2-ETHANEDIOL1,2-ETHANEDIOL
4
2
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
5
2
7-(2,4-dimethyl-1H-imidazol-1-yl)-2-(5-{[4-(1H-pyrazol-1-yl)phenyl]methyl}-1,3-thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline7-(2,4-dimethyl-1H-imidazol-1-yl)-2-(5-{[4-(1H-pyrazol-1-yl)phenyl]methyl}-1,3-thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303