7RNI: Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen

PDB ID: 7RNIDownload
MMDB ID: 206420
PDB Deposition Date: 2021/7/29
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.978  Å
Source Organism:
Similar Structures:
Biological Unit for 7RNI: dimeric; determined by author and by software (PISA)
Molecular Components in 7RNI
Label Count Molecule
Proteins (2 molecules)
1
Protein Farnesyltransferase/geranylgeranyltransferase Type-1 Subunit Alpha
(Gene symbol: Fnta)
Molecule annotation
1
Protein Farnesyltransferase Subunit Beta
(Gene symbol: Fntb)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
2
ACETYL GROUPACETYL GROUP
2
1
[4-[[3-(2,2-dimethylpropyl)-1~{H}-benzimidazol-2-yl]methyl]piperazin-1-yl]-(1,3,5-trimethylpyrazol-4-yl)methanone[4-[[3-(2,2-dimethylpropyl)-1~{H}-benzimidazol-2-yl]methyl]piperazin-1-yl]-(1,3,5-trimethylpyrazol-4-yl)methanone
3
1
ZINC IONZINC ION
4
1
MAGNESIUM IONMAGNESIUM ION
5
1
DIMETHYLALLYL DIPHOSPHATEDIMETHYLALLYL DIPHOSPHATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303