7QPF: Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate

PDB ID: 7QPFDownload
MMDB ID: 229079
PDB Deposition Date: 2022/1/4
Updated in MMDB: 2023/04
Experimental Method:
x-ray diffraction
Resolution: 1.7  Å
Source Organism:
Similar Structures:
Biological Unit for 7QPF: monomeric; determined by author
Molecular Components in 7QPF
Label Count Molecule
Protein (1 molecule)
1
Camp and Camp-inhibited Cgmp 3',5'-cyclic Phosphodiesterase 10A
(Gene symbol: PDE10A)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
ZINC IONZINC ION
2
1
MAGNESIUM IONMAGNESIUM ION
3
1
2-(1~{H}-benzimidazol-2-ylsulfanylmethyl)-3-bromanyl-5,7-dimethyl-imidazo[1,2-a]pyrimidine2-(1~{H}-benzimidazol-2-ylsulfanylmethyl)-3-bromanyl-5,7-dimethyl-imidazo[1,2-a]pyrimidine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303