7PW4: Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor

PDB ID: 7PW4Download
MMDB ID: 209476
PDB Deposition Date: 2021/10/6
Updated in MMDB: 2025/12
Experimental Method:
electron microscopy
Resolution: 3.27  Å
Source Organism:
Similar Structures:
Biological Unit for 7PW4: trimeric; determined by author
Molecular Components in 7PW4
Label Count Molecule
Proteins (3 molecules)
1
Serine/threonine-protein Kinase Smg1,serine/threonine-protein Kinase Smg1,serine/threonine-protein Kinase Smg1,serine/threonine-protein Kinase Smg1,serine/threonine-protein Kinase Smg1,serine/threonine-protein Kinase Smg1,serine/threonine-protein Kinase Smg1,serine/threonine-protein Kinase Smg1
(Gene symbol: SMG1)
Molecule annotation
1
Protein Smg8
(Gene symbol: SMG8)
Molecule annotation
1
Protein Smg9
(Gene symbol: SMG9)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
INOSITOL HEXAKISPHOSPHATEINOSITOL HEXAKISPHOSPHATE
2
1
1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea
3
1
ADENOSINE-5'-TRIPHOSPHATEADENOSINE-5'-TRIPHOSPHATE
4
1
MAGNESIUM IONMAGNESIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303