7O2I: METTL3-METTL14 heterodimer bound to the SAM competitive small molecule inhibitor STM2457

PDB ID: 7O2IDownload
MMDB ID: 201062
PDB Deposition Date: 2021/3/30
Updated in MMDB: 2021/05
Experimental Method:
x-ray diffraction
Resolution: 3  Å
Source Organism:
Similar Structures:
Biological Unit for 7O2I: dimeric; determined by author and by software (PISA)
Molecular Components in 7O2I
Label Count Molecule
Proteins (2 molecules)
1
N6-adenosine-methyltransferase Catalytic Subunit
(Gene symbol: METTL3)
Molecule annotation
1
N6-adenosine-methyltransferase Non-catalytic Subunit
(Gene symbol: METTL14)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
~{N}-[[6-[(cyclohexylmethylamino)methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-4-oxidanylidene-1~{H}-pyrido[1,2-a]pyrimidine-2-carboxamide~{N}-[[6-[(cyclohexylmethylamino)methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-4-oxidanylidene-1~{H}-pyrido[1,2-a]pyrimidine-2-carboxamide
2
1
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303