7O22: X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 4 (mi359)

PDB ID: 7O22Download
MMDB ID: 206206
PDB Deposition Date: 2021/3/30
Updated in MMDB: 2021/10
Experimental Method:
x-ray diffraction
Resolution: 1.8  Å
Source Organism:
Similar Structures:
Biological Unit for 7O22: monomeric; determined by author and by software (PISA)
Molecular Components in 7O22
Label Count Molecule
Protein (1 molecule)
1
Furin
(Gene symbol: FURIN)
Molecule annotation
Chemicals and Non-standard biopolymers (12 molecules)
1
3
CALCIUM IONCALCIUM ION
2
2
SODIUM IONSODIUM ION
3
1
CHLORIDE IONCHLORIDE ION
4
4
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
5
1
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
6
1
[azanyl-[(2E)-2-[[2-[(4-chlorophenyl)methoxy]phenyl]methylidene]hydrazinyl]methylidene]azanium[azanyl-[(2E)-2-[[2-[(4-chlorophenyl)methoxy]phenyl]methylidene]hydrazinyl]methylidene]azanium
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303