7O1U: X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 1 (BEV241)

PDB ID: 7O1UDownload
MMDB ID: 206201
PDB Deposition Date: 2021/3/30
Updated in MMDB: 2021/10
Experimental Method:
x-ray diffraction
Resolution: 1.7  Å
Source Organism:
Similar Structures:
Biological Unit for 7O1U: monomeric; determined by author and by software (PISA)
Molecular Components in 7O1U
Label Count Molecule
Protein (1 molecule)
1
Furin
(Gene symbol: FURIN)
Molecule annotation
Chemicals and Non-standard biopolymers (14 molecules)
1
1
[[(2E)-2-[1-[3-[(E)-N-[[azaniumylidene(azanyl)methyl]amino]-C-methyl-carbonimidoyl]-5-azanyl-phenyl]ethylidene]hydrazinyl]-azanyl-methylidene]azanium[[(2E)-2-[1-[3-[(E)-N-[[azaniumylidene(azanyl)methyl]amino]-C-methyl-carbonimidoyl]-5-azanyl-phenyl]ethylidene]hydrazinyl]-azanyl-methylidene]azanium
2
3
CALCIUM IONCALCIUM ION
3
4
SODIUM IONSODIUM ION
4
1
CHLORIDE IONCHLORIDE ION
5
4
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
6
1
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303