7NXK: Crystal structure of human Cdk12/Cyclin K in complex with the inhibitor BSJ-01-175

PDB ID: 7NXKDownload
MMDB ID: 201969
PDB Deposition Date: 2021/3/18
Updated in MMDB: 2025/12
Experimental Method:
x-ray diffraction
Resolution: 3  Å
Source Organism:
Similar Structures:
Biological Unit for 7NXK: dimeric; determined by author
Molecular Components in 7NXK
Label Count Molecule
Proteins (2 molecules)
1
Cyclin-dependent Kinase 12
(Gene symbol: CDK12)
Molecule annotation
1
Cyclin-k
(Gene symbol: CCNK)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(E)-N-[4-[(1R,3R)-3-[[5-chloranyl-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]cyclohexyl]oxyphenyl]-4-(dimethylamino)but-2-enamide(E)-N-[4-[(1R,3R)-3-[[5-chloranyl-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]cyclohexyl]oxyphenyl]-4-(dimethylamino)but-2-enamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303