7ND1: First-in-class small molecule inhibitors of Polycomb Repressive Complex 1 (PRC1) RING domain

PDB ID: 7ND1Download
MMDB ID: 203236
PDB Deposition Date: 2021/1/29
Updated in MMDB: 2021/07
Experimental Method:
solution nmr
Source Organism:
Similar Structures:
Biological Unit for 7ND1: dimeric; determined by author
Molecular Components in 7ND1
Label Count Molecule
Proteins (2 molecules)
1
E3 Ubiquitin-protein Ligase Ring2
(Gene symbol: RNF2)
Molecule annotation
1
Polycomb Complex Protein Bmi-1
(Gene symbol: BMI1)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
4
ZINC IONZINC ION
2
1
3-(2-chlorophenyl)-4-ethyl-5-(1~{H}-indol-4-yl)-1~{H}-pyrrole-2-carboxylic acid3-(2-chlorophenyl)-4-ethyl-5-(1~{H}-indol-4-yl)-1~{H}-pyrrole-2-carboxylic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303