7MEU: A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders

PDB ID: 7MEUDownload
MMDB ID: 201503
PDB Deposition Date: 2021/4/7
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.91  Å
Source Organism:
Similar Structures:
Biological Unit for 7MEU: monomeric; determined by author and by software (PISA)
Molecular Components in 7MEU
Label Count Molecule
Protein (1 molecule)
1
Eukaryotic Translation Initiation Factor 4E
(Gene symbol: EIF4E)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
7-METHYL-GUANOSINE-5'-TRIPHOSPHATE7-METHYL-GUANOSINE-5'-TRIPHOSPHATE
2
1
(2E)-2-{2-[4-([1,1'-biphenyl]-4-yl)-1,3-thiazol-2-yl]hydrazinylidene}-3-(2-nitrophenyl)propanoic acid(2E)-2-{2-[4-([1,1'-biphenyl]-4-yl)-1,3-thiazol-2-yl]hydrazinylidene}-3-(2-nitrophenyl)propanoic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303