7M2N: Crystal structure of Human Lactate Dehydrogenase A with Inhibitor Compound 15

PDB ID: 7M2NDownload
MMDB ID: 204552
PDB Deposition Date: 2021/3/17
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Similar Structures:
Biological Unit for 7M2N: tetrameric; determined by author and by software (PISA)
Molecular Components in 7M2N
Label Count Molecule
Proteins (4 molecules)
4
L-lactate Dehydrogenase a Chain
(Gene symbol: LDHA)
Molecule annotation
Chemicals and Non-standard biopolymers (105 molecules)
1
4
1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE
2
10
SULFATE IONSULFATE ION
3
75
1,2-ETHANEDIOL1,2-ETHANEDIOL
4
6
GLYCEROLGLYCEROL
5
6
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
6
4
5-[(5'-{1-(4-carboxy-1,3-thiazol-2-yl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-3-yl}-2'-fluoro[1,1'-biphenyl]-4-yl)oxy]-1H-1,2,3-triazole-4-carboxylic acid5-[(5'-{1-(4-carboxy-1,3-thiazol-2-yl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-3-yl}-2'-fluoro[1,1'-biphenyl]-4-yl)oxy]-1H-1,2,3-triazole-4-carboxylic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303