7M0Y: Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Trametinib

PDB ID: 7M0YDownload
MMDB ID: 201268
PDB Deposition Date: 2021/3/11
Updated in MMDB: 2021/11
Experimental Method:
x-ray diffraction
Resolution: 3.45  Å
Source Organism:
Similar Structures:
Biological Unit for 7M0Y: dimeric; determined by author and by software (PISA)
Molecular Components in 7M0Y
Label Count Molecule
Proteins (2 molecules)
1
Serine/threonine-protein Kinase B-raf
(Gene symbol: BRAF)
Molecule annotation
1
Dual Specificity Mitogen-activated Protein Kinase Kinase 1
(Gene symbol: MAP2K1)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
2
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTERPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
2
2
MAGNESIUM IONMAGNESIUM ION
3
1
SULFATE IONSULFATE ION
4
1
TrametinibTrametinib
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303