7LXL: Crystal structure of human CYP3A4 bound to the testosterone dimer

PDB ID: 7LXLDownload
MMDB ID: 201499
PDB Deposition Date: 2021/3/4
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.75  Å
Source Organism:
Similar Structures:
Biological Unit for 7LXL: dimeric; determined by author
Molecular Components in 7LXL
Label Count Molecule
Proteins (2 molecules)
2
Cytochrome P450 3A4
(Gene symbol: CYP3A4)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
PROTOPORPHYRIN IX CONTAINING FEPROTOPORPHYRIN IX CONTAINING FE
2
2
17alpha-hydroxy-7alpha-[(2Z)-4-(17beta-hydroxy-3-oxo-8alpha-androst-4-en-7beta-yl)but-2-en-1-yl]-8alpha,10alpha,13alpha,14beta-androst-4-en-3-one17alpha-hydroxy-7alpha-[(2Z)-4-(17beta-hydroxy-3-oxo-8alpha-androst-4-en-7beta-yl)but-2-en-1-yl]-8alpha,10alpha,13alpha,14beta-androst-4-en-3-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303