7LRL: Co-complex CYP46A1 with 7742 (Soticlestat/TAK-935))

PDB ID: 7LRLDownload
MMDB ID: 205904
PDB Deposition Date: 2021/2/16
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.995  Å
Source Organism:
Similar Structures:
Biological Unit for 7LRL: monomeric; determined by author and by software (PISA)
Molecular Components in 7LRL
Label Count Molecule
Protein (1 molecule)
1
Cholesterol 24-hydroxylase
(Gene symbol: CYP46A1)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
PROTOPORPHYRIN IX CONTAINING FEPROTOPORPHYRIN IX CONTAINING FE
2
1
[4-oxidanyl-4-(phenylmethyl)piperidin-1-yl]-(2-pyridin-4-ylpyridin-3-yl)methanone[4-oxidanyl-4-(phenylmethyl)piperidin-1-yl]-(2-pyridin-4-ylpyridin-3-yl)methanone
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303