7LM2: HUMAN PI3KDELTA IN COMPLEX WITH COMPOUND 3C

PDB ID: 7LM2Download
MMDB ID: 201254
PDB Deposition Date: 2021/2/5
Updated in MMDB: 2021/05
Experimental Method:
x-ray diffraction
Resolution: 2.79  Å
Source Organism:
Similar Structures:
Biological Unit for 7LM2: dimeric; determined by author and by software (PISA)
Molecular Components in 7LM2
Label Count Molecule
Proteins (2 molecules)
1
Phosphatidylinositol 4,5-bisphosphate 3-kinase Catalytic Subunit Delta Isoform
(Gene symbol: PIK3CD)
Molecule annotation
1
Phosphatidylinositol 3-kinase Regulatory Subunit Alpha
(Gene symbol: PIK3R1)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
cyclopropyl[(3S)-3-{[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]amino}pyrrolidin-1-yl]methanonecyclopropyl[(3S)-3-{[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]amino}pyrrolidin-1-yl]methanone
2
1
1,2-ETHANEDIOL1,2-ETHANEDIOL
3
1
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303