7LJC: Allosteric modulator LY3154207 binding to SKF-81297-bound dopamine receptor 1 in complex with miniGs protein

PDB ID: 7LJCDownload
MMDB ID: 199451
PDB Deposition Date: 2021
Updated in MMDB: 2024/12
Experimental Method:
electron microscopy
Resolution: 3  Å
Source Organism:
Rattus norvegicus▼
Similar Structures:
Biological Unit for 7LJC: pentameric; determined by author
Molecular Components in 7LJC
Label Count Molecule
Proteins (5 molecules)
1
D(1a) Dopamine Receptor
Molecule annotation
1
Engineered Human GS Alpha Subunit
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
Molecule annotation
1
Nanoboy 35
Molecule annotation
Chemicals and Non-standard biopolymers (14 molecules)
1
1
(1R)-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol(1R)-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
2
1
2-[2,6-bis(chloranyl)phenyl]-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone2-[2,6-bis(chloranyl)phenyl]-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone
3
6
CHOLESTEROLCHOLESTEROL
4
6
PALMITIC ACIDPALMITIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303