7L1A: Human Methionine Adenosyltransferase 2A bound to Methylthioadenosine and inhibitor, di-imido triphosphate (PNPNP)

PDB ID: 7L1ADownload
MMDB ID: 199987
PDB Deposition Date: 2020/12/14
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.25  Å
Source Organism:
Similar Structures:
Biological Unit for 7L1A: dimeric; determined by author and by software (PISA)
Molecular Components in 7L1A
Label Count Molecule
Proteins (2 molecules)
2
S-adenosylmethionine Synthase Isoform Type-2
(Gene symbol: MAT2A)
Molecule annotation
Chemicals and Non-standard biopolymers (24 molecules)
1
4
MAGNESIUM IONMAGNESIUM ION
2
2
POTASSIUM IONPOTASSIUM ION
3
2
N,N'-(dihydroxy-lambda~5~-phosphanediyl)bis(phosphoramidic acid)N,N'-(dihydroxy-lambda~5~-phosphanediyl)bis(phosphoramidic acid)
4
2
5'-DEOXY-5'-METHYLTHIOADENOSINE5'-DEOXY-5'-METHYLTHIOADENOSINE
5
2
ALANINEALANINE
6
12
SODIUM IONSODIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303