7KZ4: Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM705 (N-(1-(1H-1,2,4-triazol-3-yl)ethyl)-3-methyl-4-(1-(6-(trifluoromethyl)pyridin-3-yl)cyclopropyl)-1H-pyrrole-2-carboxamide)

PDB ID: 7KZ4Download
MMDB ID: 202157
PDB Deposition Date: 2020/12/9
Updated in MMDB: 2021/12
Experimental Method:
x-ray diffraction
Resolution: 1.75  Å
Source Organism:
Similar Structures:
Biological Unit for 7KZ4: monomeric; determined by author and by software (PISA)
Molecular Components in 7KZ4
Label Count Molecule
Protein (1 molecule)
1
Dihydroorotate Dehydrogenase (Quinone), Mitochondrial
(Gene symbol: PF3D7_0603300)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
3-methyl-N-[(1R)-1-(1H-1,2,4-triazol-3-yl)ethyl]-4-{1-[6-(trifluoromethyl)pyridin-3-yl]cyclopropyl}-1H-pyrrole-2-carboxamide3-methyl-N-[(1R)-1-(1H-1,2,4-triazol-3-yl)ethyl]-4-{1-[6-(trifluoromethyl)pyridin-3-yl]cyclopropyl}-1H-pyrrole-2-carboxamide
2
1
FLAVIN MONONUCLEOTIDEFLAVIN MONONUCLEOTIDE
3
1
OROTIC ACIDOROTIC ACID
4
1
MAGNESIUM IONMAGNESIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303