7KPU: Crystal structure of human NatD (NAA40) bound to a bisubstrate analogue with a C-3 linker

PDB ID: 7KPUDownload
MMDB ID: 203193
PDB Deposition Date: 2020/11/12
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.43  Å
Source Organism:
Similar Structures:
Biological Unit for 7KPU: dimeric; determined by author
Molecular Components in 7KPU
Label Count Molecule
Proteins (2 molecules)
1
N-alpha-acetyltransferase 40
(Gene symbol: NAA40)
Molecule annotation
1
Bisubstrate Analogue (Cmc-ace-ser-gly-arg-gly-lys)
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
2
SULFATE IONSULFATE ION
2
1
2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
3
1
[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R)-3-hydroxy-2,2-dimethyl-4-[(3-{[2-(methylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-4-oxobutyl dihydrogen diphosphate (non-preferred name)[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R)-3-hydroxy-2,2-dimethyl-4-[(3-{[2-(methylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-4-oxobutyl dihydrogen diphosphate (non-preferred name)
4
1
AMINO GROUPAMINO GROUP
5
1
ACETYL GROUPACETYL GROUP
6
1
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303