7KID: PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 72

PDB ID: 7KIDDownload
MMDB ID: 201229
PDB Deposition Date: 2020/10/23
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Similar Structures:
Biological Unit for 7KID: dimeric; determined by author and by software (PISA)
Molecular Components in 7KID
Label Count Molecule
Proteins (2 molecules)
1
Protein Arginine N-methyltransferase 5
(Gene symbol: PRMT5)
Molecule annotation
1
Methylosome Protein 50
(Gene symbol: WDR77)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
4
1,2-ETHANEDIOL1,2-ETHANEDIOL
2
1
(1S,2R,3aR,4S,6aR)-4-[(2-amino-3,5-difluoroquinolin-7-yl)methyl]-2-(4-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydropentalene-1,6a(1H)-diol(1S,2R,3aR,4S,6aR)-4-[(2-amino-3,5-difluoroquinolin-7-yl)methyl]-2-(4-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydropentalene-1,6a(1H)-diol
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303