7KIB: PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 4

PDB ID: 7KIBDownload
MMDB ID: 201227
PDB Deposition Date: 2020/10/23
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.52  Å
Source Organism:
Similar Structures:
Biological Unit for 7KIB: dimeric; determined by author and by software (PISA)
Molecular Components in 7KIB
Label Count Molecule
Proteins (2 molecules)
1
Protein Arginine N-methyltransferase 5
(Gene symbol: PRMT5)
Molecule annotation
1
Methylosome Protein 50
(Gene symbol: WDR77)
Molecule annotation
Chemicals and Non-standard biopolymers (16 molecules)
1
1
(2R,3R,3aS,6S,6aR)-6-[(2-amino-3-bromoquinolin-7-yl)oxy]-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydro-3aH-cyclopenta[b]furan-3,3a-diol(2R,3R,3aS,6S,6aR)-6-[(2-amino-3-bromoquinolin-7-yl)oxy]-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydro-3aH-cyclopenta[b]furan-3,3a-diol
2
10
1,2-ETHANEDIOL1,2-ETHANEDIOL
3
3
CHLORIDE IONCHLORIDE ION
4
2
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303