7KHR: Cryo-EM structure of bafilomycin A1-bound intact V-ATPase from bovine brain

PDB ID: 7KHRDownload
MMDB ID: 199976
PDB Deposition Date: 2020/10/21
Updated in MMDB: 2021/10
Experimental Method:
electron microscopy
Resolution: 3.62  Å
Source Organism:
Similar Structures:
Biological Unit for 7KHR: 32-meric; determined by author
Molecular Components in 7KHR
Label Count Molecule
Proteins (32 molecules)
3
V-type Proton Atpase Catalytic Subunit a
(Gene symbol: ATP6V1A)
Molecule annotation
3
V-type Proton Atpase Subunit B, Brain Isoform
(Gene symbol: ATP6V1B2)
Molecule annotation
1
V-type Proton Atpase Subunit C 1
(Gene symbol: ATP6V1C1)
Molecule annotation
1
V-type Proton Atpase Subunit D
Molecule annotation
3
V-type Proton Atpase Subunit E 1
(Gene symbol: ATP6V1E1)
Molecule annotation
1
V-type Proton Atpase Subunit F
(Gene symbol: ATP6V1F)
Molecule annotation
3
V-type Proton Atpase Subunit G
(Gene symbol: ATP6V1G2)
Molecule annotation
1
V-type Proton Atpase Subunit H
Molecule annotation
1
V-type Proton Atpase Subunit a
Molecule annotation
1
V-type Proton Atpase 21 KDA Proteolipid Subunit
(Gene symbol: ATP6V0B)
Molecule annotation
1
V-type Proton Atpase Subunit D 1
(Gene symbol: ATP6V0D1)
Molecule annotation
1
V-type Proton Atpase Subunit E 2
(Gene symbol: ATP6V0E2)
Molecule annotation
1
V-type Proton Atpase Subunit S1
(Gene symbol: ATP6AP1)
Molecule annotation
1
Renin Receptor
(Gene symbol: ATP6AP2)
Molecule annotation
9
V-type Proton Atpase 16 KDA Proteolipid Subunit
(Gene symbol: ATP6V0C)
Molecule annotation
1
Ribonuclease Kappa
(Gene symbol: RNASEK)
Molecule annotation
Chemicals and Non-standard biopolymers (36 molecules)
1
9
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
1
beta-D-mannopyranosebeta-D-mannopyranose
3
5
alpha-D-mannopyranosealpha-D-mannopyranose
4
3
alpha-D-glucopyranosealpha-D-glucopyranose
5
1
MAGNESIUM IONMAGNESIUM ION
6
1
ADENOSINE-5'-DIPHOSPHATEADENOSINE-5'-DIPHOSPHATE
7
1
methyl (3R,6Z,10E,14E)-3,7,11,15,19-pentamethylicosa-6,10,14,18-tetraen-1-yl dihydrogen diphosphatemethyl (3R,6Z,10E,14E)-3,7,11,15,19-pentamethylicosa-6,10,14,18-tetraen-1-yl dihydrogen diphosphate
8
8
(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate
9
1
OLEIC ACIDOLEIC ACID
10
6
(5R)-2,4-dideoxy-1-C-{(2S,3R,4S)-3-hydroxy-4-[(2R,3S,4E,6E,9R,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl}-4-methyl-5-propan-2-yl-alpha-D-threo-pentopyranose(5R)-2,4-dideoxy-1-C-{(2S,3R,4S)-3-hydroxy-4-[(2R,3S,4E,6E,9R,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl}-4-methyl-5-propan-2-yl-alpha-D-threo-pentopyranose
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303