7KDA: Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor compound 34

PDB ID: 7KDADownload
MMDB ID: 201224
PDB Deposition Date: 2020/10/8
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.24  Å
Source Organism:
Similar Structures:
Biological Unit for 7KDA: dimeric; determined by author and by software (PISA)
Molecular Components in 7KDA
Label Count Molecule
Proteins (2 molecules)
2
S-adenosylmethionine Synthase Isoform Type-2
(Gene symbol: MAT2A)
Molecule annotation
Chemicals and Non-standard biopolymers (10 molecules)
1
2
S-ADENOSYLMETHIONINES-ADENOSYLMETHIONINE
2
2
CHLORIDE IONCHLORIDE ION
3
2
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
4
2
GLYCEROLGLYCEROL
5
2
2,3-diphenyl-5-[(1H-pyrazol-3-yl)amino]pyrazolo[1,5-a]pyrimidin-7(4H)-one2,3-diphenyl-5-[(1H-pyrazol-3-yl)amino]pyrazolo[1,5-a]pyrimidin-7(4H)-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303