7K7L: Structure of a hit for G Protein Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure

PDB ID: 7K7LDownload
MMDB ID: 194509
PDB Deposition Date: 2020/9/23
Updated in MMDB: 2020/12
Experimental Method:
x-ray diffraction
Resolution: 2.539  Å
Source Organism:
Similar Structures:
Biological Unit for 7K7L: trimeric; determined by author and by software (PISA)
Molecular Components in 7K7L
Label Count Molecule
Proteins (3 molecules)
1
Beta-adrenergic Receptor Kinase 1
(Gene symbol: GRK2)
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
(Gene symbol: GNB1)
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
(Gene symbol: GNG2)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
MAGNESIUM IONMAGNESIUM ION
2
1
3-benzyl-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one3-benzyl-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303