7K6N: Crystal structure of PI3Kalpha selective Inhibitor 11-1575

PDB ID: 7K6NDownload
MMDB ID: 197162
PDB Deposition Date: 2020/9/21
Updated in MMDB: 2024/04
Experimental Method:
x-ray diffraction
Resolution: 2.77  Å
Source Organism:
Similar Structures:
Biological Unit for 7K6N: monomeric; determined by author and by software (PISA)
Molecular Components in 7K6N
Label Count Molecule
Protein (1 molecule)
1
Phosphatidylinositol 4,5-bisphosphate 3-kinase Catalytic Subunit Alpha Isoform
(Gene symbol: PIK3CA)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
tert-butyl (3S)-3-[4-(2-aminopyrimidin-5-yl)-2-(morpholin-4-yl)-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-3-methylpyrrolidine-1-carboxylatetert-butyl (3S)-3-[4-(2-aminopyrimidin-5-yl)-2-(morpholin-4-yl)-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-3-methylpyrrolidine-1-carboxylate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303