7K66: Structure of Blood Coagulation Factor VIII in Complex with an Anti-C1 Domain Pathogenic Antibody Inhibitor

PDB ID: 7K66Download
MMDB ID: 194290
PDB Deposition Date: 2020/9/18
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 3.92  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 7K66: trimeric; determined by author and by software (PISA)
Molecular Components in 7K66
Label Count Molecule
Proteins (3 molecules)
1
Coagulation Factor Viii,coagulation Factor Viii,coagulation Factor Viii,coagulation Factor Viii
Molecule annotation
1
2A9 Heavy Chain
Molecule annotation
1
2A9 Light Chain
Molecule annotation
Chemicals and Non-standard biopolymers (11 molecules)
1
5
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
1
beta-D-mannopyranosebeta-D-mannopyranose
3
2
alpha-D-mannopyranosealpha-D-mannopyranose
4
1
COPPER (II) IONCOPPER (II) ION
5
1
CALCIUM IONCALCIUM ION
6
1
ZINC IONZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303