7K4F: Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor 31

PDB ID: 7K4FDownload
MMDB ID: 196278
PDB Deposition Date: 2020/9/15
Updated in MMDB: 2025/06
Experimental Method:
electron microscopy
Resolution: 3.75  Å
Source Organism:
Similar Structures:
Biological Unit for 7K4F: tetrameric; determined by author
Molecular Components in 7K4F
Label Count Molecule
Proteins (4 molecules)
4
Transient Receptor Potential Cation Channel Subfamily V Member 6
(Gene symbol: TRPV6)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
5
5-[(4-{cis-4-[3-(trifluoromethyl)phenyl]cyclohexyl}piperazin-1-yl)methyl]pyridin-2(1H)-one5-[(4-{cis-4-[3-(trifluoromethyl)phenyl]cyclohexyl}piperazin-1-yl)methyl]pyridin-2(1H)-one
2
1
CALCIUM IONCALCIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303