7K4B: Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor cis-22a

PDB ID: 7K4BDownload
MMDB ID: 196274
PDB Deposition Date: 2020/9/15
Updated in MMDB: 2025/05
Experimental Method:
electron microscopy
Resolution: 3.1  Å
Source Organism:
Similar Structures:
Biological Unit for 7K4B: tetrameric; determined by author
Molecular Components in 7K4B
Label Count Molecule
Proteins (4 molecules)
4
Transient Receptor Potential Cation Channel Subfamily V Member 6
(Gene symbol: TRPV6)
Molecule annotation
Chemicals and Non-standard biopolymers (62 molecules)
1
5
1-[cis-4-(3-methylphenyl)cyclohexyl]-4-(pyridin-3-yl)piperazine1-[cis-4-(3-methylphenyl)cyclohexyl]-4-(pyridin-3-yl)piperazine
2
8
CHOLESTEROL HEMISUCCINATECHOLESTEROL HEMISUCCINATE
3
48
1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
4
1
CALCIUM IONCALCIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303