7K1I: EGFR kinase (L858R/V948R) in complex with allosteric inhibitor JBJ-09-063

PDB ID: 7K1IDownload
MMDB ID: 206499
PDB Deposition Date: 2020/9/7
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 3.202  Å
Source Organism:
Similar Structures:
Biological Unit for 7K1I: dimeric; determined by author and by software (PISA)
Molecular Components in 7K1I
Label Count Molecule
Proteins (2 molecules)
2
Epidermal Growth Factor Receptor
(Gene symbol: EGFR)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
2
MAGNESIUM IONMAGNESIUM ION
2
2
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTERPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
3
2
(2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{6-[4-(1-methylpiperidin-4-yl)phenyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide(2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{6-[4-(1-methylpiperidin-4-yl)phenyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303