7K0V: Crystal structure of bRaf in complex with inhibitor GNE-0749

PDB ID: 7K0VDownload
MMDB ID: 202470
PDB Deposition Date: 2020/9/6
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.93  Å
Source Organism:
Similar Structures:
Biological Unit for 7K0V: tetrameric; determined by author and by software (PISA)
Molecular Components in 7K0V
Label Count Molecule
Proteins (4 molecules)
4
Non-specific Serine/threonine Protein Kinase
(Gene symbol: BRAF)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
4
N-(3,3-dimethylbutyl)-N'-{2-fluoro-5-[(5-fluoro-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]-4-methylphenyl}ureaN-(3,3-dimethylbutyl)-N'-{2-fluoro-5-[(5-fluoro-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]-4-methylphenyl}urea
2
2
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303