7JXM: EGFR kinase (T790M/V948R) in complex with osimertinib and EAI045

PDB ID: 7JXMDownload
MMDB ID: 206327
PDB Deposition Date: 2020/8/27
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.192  Å
Source Organism:
Similar Structures:
Biological Unit for 7JXM: dimeric; determined by author and by software (PISA)
Molecular Components in 7JXM
Label Count Molecule
Proteins (2 molecules)
2
Epidermal Growth Factor Receptor
(Gene symbol: EGFR)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
2
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTERPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
2
2
MAGNESIUM IONMAGNESIUM ION
3
1
(2R)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide(2R)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303