7JVM: Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor TNO155

PDB ID: 7JVMDownload
MMDB ID: 193241
PDB Deposition Date: 2020/8/21
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.166  Å
Source Organism:
Similar Structures:
Biological Unit for 7JVM: monomeric; determined by author and by software (PISA)
Molecular Components in 7JVM
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Phosphatase Non-receptor Type 11
(Gene symbol: PTPN11)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
(3S,4S)-8-{6-amino-5-[(2-amino-3-chloropyridin-4-yl)sulfanyl]pyrazin-2-yl}-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine(3S,4S)-8-{6-amino-5-[(2-amino-3-chloropyridin-4-yl)sulfanyl]pyrazin-2-yl}-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine
2
3
PHOSPHATE IONPHOSPHATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303