7JV0: Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor PD0325901

PDB ID: 7JV0Download
MMDB ID: 193807
PDB Deposition Date: 2020/8/20
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 3.63  Å
Source Organism:
Oryctolagus cuniculus▼
Similar Structures:
Biological Unit for 7JV0: dimeric; determined by author and by software (PISA)
Molecular Components in 7JV0
Label Count Molecule
Proteins (2 molecules)
1
Kinase Suppressor of RAS 1
Molecule annotation
1
Dual Specificity Mitogen-activated Protein Kinase Kinase 1
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTERPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
2
1
MAGNESIUM IONMAGNESIUM ION
3
1
N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamideN-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303