7JUY: Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Cobimetinib

PDB ID: 7JUYDownload
MMDB ID: 193794
PDB Deposition Date: 2020/8/20
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 3.096  Å
Source Organism:
Oryctolagus cuniculus▼
Similar Structures:
Biological Unit for 7JUY: dimeric; determined by author and by software (PISA)
Molecular Components in 7JUY
Label Count Molecule
Proteins (2 molecules)
1
Kinase Suppressor of RAS 1
Molecule annotation
1
Dual Specificity Mitogen-activated Protein Kinase Kinase 1
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
2
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTERPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
2
2
MAGNESIUM IONMAGNESIUM ION
3
1
[3,4-BIS(FLUORANYL)-2-[(2-FLUORANYL-4-IODANYL-PHENYL)AMINO]PHENYL]-[3-OXIDANYL-3-[(2S)-PIPERIDIN-2-YL]AZETIDIN-1-YL]METHANONE[3,4-BIS(FLUORANYL)-2-[(2-FLUORANYL-4-IODANYL-PHENYL)AMINO]PHENYL]-[3-OXIDANYL-3-[(2S)-PIPERIDIN-2-YL]AZETIDIN-1-YL]METHANONE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303