7JUV: Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor APS-9-95-1

PDB ID: 7JUVDownload
MMDB ID: 193551
PDB Deposition Date: 2020/8/20
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 3.36  Å
Source Organism:
Oryctolagus cuniculus▼
Similar Structures:
Biological Unit for 7JUV: dimeric; determined by author and by software (PISA)
Molecular Components in 7JUV
Label Count Molecule
Proteins (2 molecules)
1
Kinase Suppressor of RAS 2
Molecule annotation
1
Dual Specificity Mitogen-activated Protein Kinase Kinase 1
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
2
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTERPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
2
2
MAGNESIUM IONMAGNESIUM ION
3
1
N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)-N'-methylsulfuric diamideN-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)-N'-methylsulfuric diamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303