7JUT: Crystal Structure of KSR2:MEK1 in complex with ANP-PNP, and allosteric MEK inhibitor Selumetinib

PDB ID: 7JUTDownload
MMDB ID: 193549
PDB Deposition Date: 2020/8/20
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 3.09  Å
Source Organism:
Oryctolagus cuniculus▼
Similar Structures:
Biological Unit for 7JUT: dimeric; determined by author and by software (PISA)
Molecular Components in 7JUT
Label Count Molecule
Proteins (2 molecules)
1
Kinase Suppressor of RAS 2
Molecule annotation
1
Dual Specificity Mitogen-activated Protein Kinase Kinase 1
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
2
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTERPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
2
1
5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303