7JL2: Cryo-EM structure of MDA5-dsRNA filament in complex with TRIM65 PSpry domain (Trimer)

PDB ID: 7JL2Download
MMDB ID: 196258
PDB Deposition Date: 2020/7/29
Updated in MMDB: 2025/06
Experimental Method:
electron microscopy
Resolution: 4.3  Å
Source Organism:
Similar Structures:
Biological Unit for 7JL2: octameric; determined by author
Molecular Components in 7JL2
Label Count Molecule
Proteins (6 molecules)
3
Interferon-induced Helicase C Domain-containing Protein 1
(Gene symbol: IFIH1)
Molecule annotation
3
Tripartite Motif-containing Protein 65
(Gene symbol: TRIM65)
Molecule annotation
Nucleotides(2 molecules)
1
RNA (44-mer)
Molecule annotation
1
RNA (44-mer)
Molecule annotation
Chemicals and Non-standard biopolymers (12 molecules)
1
3
ZINC IONZINC ION
2
3
ADENOSINE-5'-DIPHOSPHATEADENOSINE-5'-DIPHOSPHATE
3
3
TETRAFLUOROALUMINATE IONTETRAFLUOROALUMINATE ION
4
3
MAGNESIUM IONMAGNESIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303