7JHG: Cryo-EM structure of ATP-bound fully inactive AMPK in complex with Dorsomorphin (Compound C) and Fab-nanobody

PDB ID: 7JHGDownload
MMDB ID: 204727
PDB Deposition Date: 2020/7/20
Updated in MMDB: 2021/12
Experimental Method:
electron microscopy
Resolution: 3.47  Å
Source Organism:
Escherichia coli K-12▼
Similar Structures:
Biological Unit for 7JHG: heptameric; determined by author
Molecular Components in 7JHG
Label Count Molecule
Proteins (7 molecules)
1
5'-amp-activated Protein Kinase Catalytic Subunit Alpha-1
Molecule annotation
1
5'-amp-activated Protein Kinase Subunit Beta-2
Molecule annotation
1
5'-amp-activated Protein Kinase Subunit Gamma-1
Molecule annotation
1
Maltodextrin-binding Protein
Molecule annotation
1
FAB Light Chain
Molecule annotation
1
FAB Heavy Chain
Molecule annotation
1
Nanobody
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
2
alpha-D-glucopyranosealpha-D-glucopyranose
2
1
6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
3
1
ADENOSINE-5'-TRIPHOSPHATEADENOSINE-5'-TRIPHOSPHATE
4
1
ADENOSINE-5'-DIPHOSPHATEADENOSINE-5'-DIPHOSPHATE
5
1
ADENOSINE MONOPHOSPHATEADENOSINE MONOPHOSPHATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303