7G6T: Crystal Structure of rat Autotaxin in complex with 2,4-dichloro-N-phenyl-5-piperidin-1-ylsulfonylbenzamide, i.e. SMILES S(=O)(=O)(c1cc(C(=O)Nc2ccccc2)c(cc1Cl)Cl)N1CCCCC1 with IC50=3.54684 microM

PDB ID: 7G6TDownload
MMDB ID: 256802
PDB Deposition Date: 2023/6/5
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 2.01  Å
Source Organism:
Similar Structures:
Biological Unit for 7G6T: monomeric; determined by author and by software (PISA)
Molecular Components in 7G6T
Label Count Molecule
Protein (1 molecule)
1
Isoform 2 of Ectonucleotide Pyrophosphatase/phosphodiesterase Family Member 2
(Gene symbol: Enpp2)
Molecule annotation
Chemicals and Non-standard biopolymers (15 molecules)
1
2
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
1
beta-D-mannopyranosebeta-D-mannopyranose
3
5
alpha-D-mannopyranosealpha-D-mannopyranose
4
1
2,4-dichloro-N-phenyl-5-(piperidine-1-sulfonyl)benzamide2,4-dichloro-N-phenyl-5-(piperidine-1-sulfonyl)benzamide
5
1
CHLORIDE IONCHLORIDE ION
6
1
ACETATE IONACETATE ION
7
1
ZINC IONZINC ION
8
2
SODIUM IONSODIUM ION
9
1
CALCIUM IONCALCIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303