7G1W: Crystal Structure of human FABP4 binding site mutated to that of FABP5 in complex with 5-(3,5-dichloroanilino)-3,3-dimethyl-5-oxopentanoic acid, i.e. SMILES C(=O)(Nc1cc(cc(c1)Cl)Cl)CC(CC(=O)O)(C)C with IC50=4.4 microM

PDB ID: 7G1WDownload
MMDB ID: 231478
PDB Deposition Date: 2023/4/27
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 1.34  Å
Source Organism:
Similar Structures:
Biological Unit for 7G1W: monomeric; determined by author and by software (PISA)
Molecular Components in 7G1W
Label Count Molecule
Protein (1 molecule)
1
Fatty Acid-binding Protein, Adipocyte
(Gene symbol: FABP4)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
5-(3,5-dichloroanilino)-3,3-dimethyl-5-oxopentanoic acid5-(3,5-dichloroanilino)-3,3-dimethyl-5-oxopentanoic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303