7F4H: Cryo-EM structure of afamelanotide-bound melanocortin-1 receptor in complex with Gs protein, Nb35 and scFv16

PDB ID: 7F4HDownload
MMDB ID: 206297
PDB Deposition Date: 2021/6/18
Updated in MMDB: 2021/09
Experimental Method:
electron microscopy
Resolution: 2.7  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 7F4H: heptameric; determined by author
Molecular Components in 7F4H
Label Count Molecule
Proteins (7 molecules)
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i) Subunit Alpha-1
Molecule annotation
1
Nanobody 35
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
Molecule annotation
1
Melanocortin-1 Receptor
Molecule annotation
1
Scfv16
Molecule annotation
1
Afamelanotide
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
CALCIUM IONCALCIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303