7F3G: Crystal structure of DCLK1 kinase domain in complex with ruxolitinib

PDB ID: 7F3GDownload
MMDB ID: 205677
PDB Deposition Date: 2021/6/16
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 7F3G: dimeric; determined by author and by software (PISA)
Molecular Components in 7F3G
Label Count Molecule
Proteins (2 molecules)
2
Isoform 4 of Serine/threonine-protein Kinase Dclk1
(Gene symbol: DCLK1)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303