7EHM: Human MTHFD2 in complex with compound 21 and 15

PDB ID: 7EHMDownload
MMDB ID: 205462
PDB Deposition Date: 2021/3/30
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.13  Å
Source Organism:
Similar Structures:
Biological Unit for 7EHM: dimeric; determined by author and by software (PISA)
Molecular Components in 7EHM
Label Count Molecule
Proteins (2 molecules)
2
Bifunctional Methylenetetrahydrofolate Dehydrogenase/cyclohydrolase, Mitochondrial
(Gene symbol: MTHFD2)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
(2S)-2-[[4-[[1-[(3,4-dichlorophenyl)methyl]-3,7-dimethyl-2,6-bis(oxidanylidene)purin-8-yl]amino]phenyl]carbonylamino]pentanedioic acid(2S)-2-[[4-[[1-[(3,4-dichlorophenyl)methyl]-3,7-dimethyl-2,6-bis(oxidanylidene)purin-8-yl]amino]phenyl]carbonylamino]pentanedioic acid
2
2
(2S)-2-[[4-[(4-azanyl-6-oxidanyl-pyrimidin-5-yl)carbamoylamino]phenyl]carbonylamino]pentanedioic acid(2S)-2-[[4-[(4-azanyl-6-oxidanyl-pyrimidin-5-yl)carbamoylamino]phenyl]carbonylamino]pentanedioic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303