7E4Q: Crystal structure of tubulin in complex with L-DM1-SMe

PDB ID: 7E4QDownload
MMDB ID: 204073
PDB Deposition Date: 2021/2/14
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.501  Å
Source Organism:
Rattus norvegicus▼
Similar Structures:
Biological Unit for 7E4Q: hexameric; determined by author
Molecular Components in 7E4Q
Label Count Molecule
Proteins (6 molecules)
2
Tubulin Alpha-1b Chain
Molecule annotation
2
Tubulin Beta-2b Chain
Molecule annotation
1
Stathmin-4
Molecule annotation
1
Tubulin Tyrosine Ligase
Molecule annotation
Chemicals and Non-standard biopolymers (14 molecules)
1
3
GUANOSINE-5'-TRIPHOSPHATEGUANOSINE-5'-TRIPHOSPHATE
2
5
MAGNESIUM IONMAGNESIUM ION
3
2
CALCIUM IONCALCIUM ION
4
1
GUANOSINE-5'-DIPHOSPHATEGUANOSINE-5'-DIPHOSPHATE
5
1
2-(N-MORPHOLINO)-ETHANESULFONIC ACID2-(N-MORPHOLINO)-ETHANESULFONIC ACID
6
1
(1S,2R,3R,5R,6R,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl (2S)-2-{methyl[3-(methyldisulfanyl)propanoyl]amino}propanoate (non-preferred name)(1S,2R,3R,5R,6R,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl (2S)-2-{methyl[3-(methyldisulfanyl)propanoyl]amino}propanoate (non-preferred name)
7
1
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTERPHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303