7E14: Compound2_GLP-1R_OWL833_Gs complex structure

PDB ID: 7E14Download
MMDB ID: 204072
PDB Deposition Date: 2021/1/30
Updated in MMDB: 2021/07
Experimental Method:
electron microscopy
Resolution: 2.9  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 7E14: pentameric; determined by author
Molecular Components in 7E14
Label Count Molecule
Proteins (5 molecules)
1
GS
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
Molecule annotation
1
G Protein
Molecule annotation
1
Nb35
Molecule annotation
1
Glucagon-like Peptide 1 Receptor
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
1
3-[(1S,2S)-1-(5-[(4S)-2,2-dimethyloxan-4-yl]-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl)-2-methylcyclopropyl]-1,2,4-oxadiazol-5(4H)-one3-[(1S,2S)-1-(5-[(4S)-2,2-dimethyloxan-4-yl]-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl)-2-methylcyclopropyl]-1,2,4-oxadiazol-5(4H)-one
2
5
CHOLESTEROLCHOLESTEROL
3
1
N-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amineN-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303