7DV6: Discovery of Functionally Selective Transforming Growth Factor beta Type II Receptor (TGF-beta RII) Inhibitors as Anti-Fibrosis Agents

PDB ID: 7DV6Download
MMDB ID: 203178
PDB Deposition Date: 2021/1/12
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.39  Å
Source Organism:
Similar Structures:
Biological Unit for 7DV6: monomeric; determined by author
Molecular Components in 7DV6
Label Count Molecule
Protein (1 molecule)
1
Tgf-beta Receptor Type-2
(Gene symbol: TGFBR2)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
5-[(3S)-5,5-dimethyloxolan-3-yl]-6-methoxy-3-(2-methoxypyridin-4-yl)pyrazolo[1,5-a]pyrimidine5-[(3S)-5,5-dimethyloxolan-3-yl]-6-methoxy-3-(2-methoxypyridin-4-yl)pyrazolo[1,5-a]pyrimidine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303